Guo, Palaniyappan et al. Anatomical distance affects functional connectivity in patients with schizophrenia and their siblings. PMID:24282323
A crucial developmental feature of the brain that occurs in normal adolescence is the selective strengthening of long-distance connections.
In patients with schizophrenia and their siblings, a disproportionate reduction in the number of long-range connections were noted. Siblings showed some evidence of compensating for this deficit.
When using pattern classification, the abnormalities in long-range connections had superior ability to accurately identify the presence of schizophrenia.
A crucial organizing principle of the brain architecture that becomes apparent during normal adolescence is disturbed in schizophrenia.
A crucial developmental feature of the brain that occurs in normal adolescence is the selective strengthening of long-distance connections.
In patients with schizophrenia and their siblings, a disproportionate reduction in the number of long-range connections were noted. Siblings showed some evidence of compensating for this deficit.
When using pattern classification, the abnormalities in long-range connections had superior ability to accurately identify the presence of schizophrenia.
A crucial organizing principle of the brain architecture that becomes apparent during normal adolescence is disturbed in schizophrenia.
- First study exploring the relationship between anatomical distance and functional connectivity in adults with schizophrenia
- Published in Schizophrenia Bulletin (IF: 8.5)