Mingli Li, Chaohua Huang,....,Lena Palaniyappan, Tao Li. . Contrasting and convergent patterns of amygdala connectivity in mania and depression: a resting-state study
Mania and depression in bipolar disorder manifest two extremes of aberrant emotional, physiologic and behavioral arousal states despite similarities in treatment response and neurocognitive deficits. We used resting-state functional magnetic resonance imaging to explore the common and unique abnormal functional connectivity underlying acute manic or depressed state in bipolar disorder.
In a brief report published in the Journal of Affective Disorders, we report the substantial overlap in the pattern of disturbed connectivity between amygdala and frontal, striatal, lingual and cerebellar regions in both groups (mania and depression). A contrasting pattern of functional connectivity between right amygdala and hippocampus (and other nearby regions) was also noted, providing a novel lead to the probable mechanistic differences in these two extremes of mood states.
Mania and depression in bipolar disorder manifest two extremes of aberrant emotional, physiologic and behavioral arousal states despite similarities in treatment response and neurocognitive deficits. We used resting-state functional magnetic resonance imaging to explore the common and unique abnormal functional connectivity underlying acute manic or depressed state in bipolar disorder.
In a brief report published in the Journal of Affective Disorders, we report the substantial overlap in the pattern of disturbed connectivity between amygdala and frontal, striatal, lingual and cerebellar regions in both groups (mania and depression). A contrasting pattern of functional connectivity between right amygdala and hippocampus (and other nearby regions) was also noted, providing a novel lead to the probable mechanistic differences in these two extremes of mood states.
- First study to report contrasting patterns of amygdala-hippocampal connectivity in bipolar depression and mania
- Published in Journal of Affective Disorders (IF:3.7)